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KMID : 0380319920500000207
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Journal of Korean Research Institute for Better Living
1992 Volume.50 No. 0 p.207 ~ p.236
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Study on Dissolution Charateristics of Indomethacin-Ethylcellulose Microcapsules
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Abstract
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Indomethacin-ethylcellulose microcapsules(IDM-MC) were prepared by solvent evaporation method using sod. lauryl sulfate(SLS) as a surfactant.
In case of IDM-MC prepared with various ratios of ethylcellulose(EC) and polyethylene glycol 4000(PEG 4000) in 0.25％ SLS solution, drug content of IDM-MC were 17.80％ to 21.25％, while those of IDM-MC prepared using EC in various concentrations of SLS solution were 11.25％ to 16.06％.
Scanning Electron Microgram showed that the IDM-MC were almost spherical and had pores on the surface.
Particle size distributions of IDM-MC were relatively regular.
The dissolution rates of IDM from the IDM-MC retarded considerably compared with that of IDM powder ; the dissolution of IDM was more than 90％ within 1 hour, but those of IDM from IDM-MC were about 20 to 70％ within 24 hours. And, the dissolution of IDM from IDM-MC prepared with EC : PEG 4000=1 : 1 and stirred in 30(w/w)％ glycerin solution was more twice than those of IDM from IDM-MC prepared without PEG 4000.
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KEYWORD
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